IMMUNOLOGY: Remodeling One's Residence

Permanent alveolar remodeling in canine lung induced by high-altitude residence during maturation.

Young canines born at sea level (SL) and raised for 5 mo at high altitude (HA, 3,800 m), followed by return to SL before somatic maturation, showed enhanced alveolar gas exchange and diffusing capacity at rest and exercise that persisted into adulthood (McDonough P, Dane DM, Hsia CC, Yilmaz C, Johnson RL Jr. J Appl Physiol 100: 474-81, 2006; Hsia CCW, Johnson RL Jr, McDonough P, Dane DM, Hurst ...

Immunology

Immunology.

The pathological changes involved in the immunological lung diseases of the bronchiolar region are reviewed. Next, the possibility that BOOP and DPB, two diseases whose causes are presently unknown, are caused by immune responses, is discussed.

Microenvironment and Immunology LOXL2-Mediated Matrix Remodeling in Metastasis and Mammary Gland Involution

More than 90% of cancer patient mortality is attributed to metastasis. In this study, we investigated a role for the lysyl oxidase-related enzyme lysyl oxidase-like 2 (LOXL2) in breast cancer metastasis, in both patient samples and in vivomodels. Analysis of a publishedmicroarray data set revealed that LOXL2 expression is correlated with metastasis and decreased survival in patients with aggres...

Immunology